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PUBLICATIONS

Title: "Efficacy of the paramunity inducers PIND-AVI and PIND-ORF as radioprotective agents"
Author: Breiter N; Ungemach FR; Beck G; Hegner D; Mayr A
Source: Strahlentherapie, 161(3):168-76 1985 Mar
Language: German
Unique Identifier: 85143150
Publication Type: JOURNAL ARTICLE
ISSN: 0039-2073
Country of Publication: GERMANY, WEST

- Abstract -
A significant reduction of mortality after lethal irradiation (7,8 and 9 Gy X-ray total-body irradiation) was achieved by continuous therapeutic subcutaneous application of the biologic inducers PIND-AVI and PIND-ORF. This was obtained by a stimulation of the investigated spleen parameters and a stimulation of leucocytes and phagocytosis. The inducers had no significant influence on the radiogenic reduction of blood cells and bone marrow cells, of the relative spleen and thymus weight and of the DNA and protein level of spleen and thymus. The regeneration of blood leucocytes (preponderantly by PIND-AVI) and of the spleen (preponderantly by PIND-ORF) was accelerated, but not the thymus regeneration which was already rather low. The leucocyte phagocytosis which increased generally after irradiation was markedly stimulated by paramunization. This stimulation was also observed after a latent time in animals submitted to sham irradiation. Its temporal appearance and its quantitative and qualitative properties corresponded to the effects of inducers after X-ray irradiation. Both inducers were found to be harmless in all experiments.


Title: "Tests on protection against viral diseases"
Author: Buttner M; Mayr A
Source: Comp Immunol Microbiol Infect Dis, 9(2-3):205-15 1986
Language: English
Unique Identifier: 87079486
Publication Type: JOURNAL ARTICLE
ISSN: 0147-9571
Country of Publication: ENGLAND

- Abstract -
Despite many attempts to find reliable in vitro criteria for the efficacy of Biological Response Modifiers--BRMs (immunomodulators, paramunity inducers) animal challenge models are still the only way to demonstrate the totality of interlocking defense mechanisms. Challenge models with mouse pathogenic viruses provide an excellent possibility to study protective effects of BRMs against acute or chronic forms of viral diseases. For comparative studies two completely different virus challenge models--Pseudorabies PR and Stomatitis Vesicularis VSV--were developed with adult and baby NMRI mice respectively. The potency of BRMs in preventing lethal disease reveals significant differences depending upon the sort of BRM, the route of application and the time of pretreatment. Defense mechanisms important for the control of Pseudorabies virus infection in adult NMRI mice were tested in vitro (ex vivo) and correlated well with the degree of protection in vivo. Comparison of BRM efficacy in selective viral challenge models combined with screening of a variety of antiviral defense functions in infected animals in vitro provide reliable methods in demonstrating the potency of BRMs against viral infections.


Title: "The influence of paramunisation' tumor cell vaccination and whole body irradiation on the growth of radiation-induced murine osteosarcoma"
Author: Erfle V; Strubel L; Luz A; Hehlmann R; Mayr A
Source: Zentralbl Veterinarmed [B , 30(1):36-47 1983 Feb
Language: English
Unique Identifier: 83199880
Publication Type: JOURNAL ARTICLE
ISSN: 0721-1856
Country of Publication: GERMANY


Title: "Effectiveness of a new "paramunity" inducer (PIND-AVI) for human beings and animals"
Author: Stickl H; Mayr A
Source: Fortschr Med, 97(40):1781-8 1979 Oct 25
Language: German
Unique Identifier: 80158135
Publication Type: JOURNAL ARTICLE
ISSN: 0015-8178
Country of Publication: GERMANY

- Abstract -
Attenuated and by treatment with gamma rays inactivated avian Pox viruses (PIND-AVI) stimulate in man and animals selectively the T-lymphocytes. In this way PIND-AVI helps to repair a reduced reactivity of lymphocytes damaged by cytostatic chemotherapy: The lymphocyte stimulation by phytohemagglutinin could be normalized. In immunodeficient patients PIND-AVI showed very good effects in the treatment of herpes Virus infections.


Title: "Comparison of the effect of viral paramunity inducers PIND-AVI and PIND-ORF with that of BCG, Corynebacterium parvum and levamisole on the growth of radiation-induced murine osteosarcoma"
Author: Muller-Brunecker G; Erfle V; Mayr A
Source: Zentralbl Veterinarmed [B], 33(3):188-95 1986 Apr
Language: English
Unique Identifier: 86318702
Publication Type: JOURNAL ARTICLE
ISSN: 0514-7166
Country of Publication: GERMANY

Title: "Use of the paramunity inducer PIND-AVI in reduced cell-mediated immunocompetence. Immunoreconstitution following cytostatic chemotherapy"
Author: Stickl H; Schleich T
Source: Fortschr Med, 103(39):907-9 1985 Oct 17
Language: German
Unique Identifier: 86057295
Publication Type: JOURNAL ARTICLE
ISSN: 0015-8178
Country of Publication: GERMANY


Title: "Tests on protection against viral diseases"
Author: Buttner M; Mayr A
Source: Comp Immunol Microbiol Infect Dis, 9(2-3):205-15 1986
Language: English
Unique Identifier: 87079486
Publication Type: JOURNAL ARTICLE
ISSN: 0147-9571
Country of Publication: ENGLAND

- Abstract -
Despite many attempts to find reliable in vitro criteria for the efficacy of Biological Response Modifiers--BRMs (immunomodulators, paramunity inducers) animal challenge models are still the only way to demonstrate the totality of interlocking defense mechanisms. Challenge models with mouse pathogenic viruses provide an excellent possibility to study protective effects of BRMs against acute or chronic forms of viral diseases. For comparative studies two completely different virus challenge models--Pseudorabies PR and Stomatitis Vesicularis VSV--were developed with adult and baby NMRI mice respectively. The potency of BRMs in preventing lethal disease reveals significant differences depending upon the sort of BRM, the route of application and the time of pretreatment. Defense mechanisms important for the control of Pseudorabies virus infection in adult NMRI mice were tested in vitro (ex vivo) and correlated well with the degree of protection in vivo. Comparison of BRM efficacy in selective viral challenge models combined with screening of a variety of antiviral defense functions in infected animals in vitro provide reliable methods in demonstrating the potency of BRMs against viral infections.


Title: "Comparative studies of the immunostimulating (paramunizing) effectiveness of BCG, levamisole, Corynebacterium parvum and preparations of pock viruses in various in vivo and in vitro tests"
Author: Mayr A; Buttner M; Pawlas S; Erfle V; Mayr B; Brunner R; Osterkorn K
Source: Zentralbl Veterinarmed [B], 33(5):321-39 1986 Jun
Language: German
Unique Identifier: 87044659
Publication Type: JOURNAL ARTICLE
ISSN: 0514-7166
Country of Publication: GERMANY


Title: "In vivo and in vitro effect of a "Biological Immunomodulator" "
Author: Jeckstadt S; Leibold W; Schroder J; Petzoldt K
Source: Berl Munch Tierarztl Wochenschr, 101(3):85-91 1988 Mar 1
Language: German
Unique Identifier: 88221655\
Publication Type: JOURNAL ARTICLE
ISSN: 0005-9366
Country of Publication: GERMANY


Title: "The influence of paramunisation' tumor cell vaccination and whole body irradiation on the growth of radiation-induced murine osteosarcoma"
Author: Erfle V; Strubel L; Luz A; Hehlmann R; Mayr A
Source: Zentralbl Veterinarmed [B , 30(1):36-47 1983 Feb
Language: English
Unique Identifier: 83199880
Publication Type: JOURNAL ARTICLE
ISSN: 0721-1856
Country of Publication: GERMANY




 

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